정제봉독의 헬리코박터 파이로리에 대한 항균활성

• 영문명: In Vitro Anti-Helicobacter pylori Activity of Purified Bee Venom Collected from Honeybee (Apis mellifera L.) Workers
• 발행기관: 대한약학회
• 저자명: 한상미(Sang Mi Han) 홍인표(In Pyo Hong) 우순옥(Soon Ok Woo) 김세건(Se Gun Kim) 장혜리(Hye Ri Jang)
• 간행물 정보: 『약학회지』제61권 제6호(2017년), 350~354쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

This study was to investigate the antimicrobial effect of purified bee venom(PBV) against Helicobacter pylori, which is known to cause gastric ulcer and stomach cancer. Antimicrobial activity was evaluated by minimum inhibitory concentration( MIC), minimum bactericidal concentration(MBC) and time-kill assay of PBV against H. pylori. As a result, there was no significant difference in the antibacterial activity between amoxycillin(positive control) and PBV that have MIC of 0.13±0.036 μg/ml and MBC of 0.26±0.042 μg/ml. In addition, PBV treatment was found to inhibit significantly growth of H. pylori after 4 hr. In order to investigate the morphological changes of H. pylori by bee venom treatment, the morphology of H. pylori was observed by scanning electron microscope(SEM). H. pylori treated with PBV was also showed that the cell wall and cell membrane were completely destroyed, and all of the cell components were leaked out, resulting in the disappearance of the bacterial form. These results suggest that PBV have significant inhibitory effects on H. pylori, and therefore, may be a potential anti-H. pylori candidate.

목차

Abstract

실험 방법

실험결과 및 고찰

결론

감사의 말씀

References

키워드

bee venom Helicobacter pylori anti-bacterial scanning electron microscope minmum inhibitory concentration minimum bactericidal concentration time-kill assay