알코올 중독 형성에 관여하는 신경생물학적 요소들에 관한 고찰

• 영문명: Neurobiological Factors Involved in the Formation of Alcoholism
• 발행기관: 대한약학회
• 저자명: 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제61권 제6호(2017년), 326~334쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

Alcoholism known as alcohol use disorder is a complex psychiatric disease with alcohol dependence and abuse. Addiction formation and the severity are determined by psychological, genetic, biological and social factors. Genetic vulnerability is important in alcoholism development. Gene candidates working on each step in addiction formation are reported by Genome-Wide Association Studies. Also, repeated drinking is reported to induce epigenetic changes. It is accepted that the major neural circuit influencing on the formation of alcoholism is the dopaminergic pathway comprising ventral tegmental area, nucleus accumbens, and prefrontal cortex. The dopaminegic system is modulated by GABA, glutamate, serotonergic neurons and opioid system. In addition, changes in dendrites, BDNF and neural cell number play an important role in the formation of alcoholism. Pharmacotherapy for alcoholism includes making alcohol ingestion unpleasant and reducing its reinforcement.

목차

Abstract

알코올 중독의 형성에 있어서 유전 인자의 영향

알코올 중독 형성과정에 스트레스가 미치는 영향

알코올 중독 형성과정에 신경회로에서 변화들

알코올 중독의 치료를 위한 약물 요법

결론

감사의 말씀

References

키워드

alcoholism neurobiological factor mechanism stress gene