실리카 나노입자의 분산조건에 따른 입도분포 변화 및 A549 세포독성

• 영문명: Size Distribution of Silica Dioxide Nanoparticles after Calibrated Sonication and Cytotoxicity in Cultured A549 Cells
• 발행기관: 대한약학회
• 저자명: 이한들(Han dule Lee) 박주영(Ju young Park) 박광식(Kwang sik Park)
• 간행물 정보: 『약학회지』제61권 제6호(2017년), 309~316쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

Size and/or size distribution is a very important factor in the cellular toxicity test of nanoparticles. Therefore, it is necessary to fulfill the requirement of standardized dispersion protocol when toxicity potencies of different types of nanoparticles are compared. In this study, different conditions including ethanol pre-wetting, concentration of bovine serum albumin in media, and measurement instruments were investigated to see the impact on the dispersity of silica nanoparticles after calibrated sonication. As results, the concentration of bovine serum albumin seemed to mostly influence the dispersion of silica nanoparticles. No significant difference was shown in cytotoxicity of cultured A549 cells among silica (SiO₂), zinc (ZnO), silver (Ag), ceria (CeO₂) and titanium (TiO₂) nanoparticles when they were dispersed by same amount of energy after calibrated sonication.

목차

Abstract

서론(Introduction)

실험 방법(Experimental Methods)

결과(Results)

고찰(Discussions)

결론(Conclusion)

감사의 글

References

키워드

nanoparticles size distribution sonication cytotoxicity