3,3`, 4,4`, 5-pentachlorobiphenyl (PCB 126)가 성장기 랫드 정소에 미치는 형태학적 변화

• 영문명: Effects of 3,3`, 4,4`, 5-pentachlorobiphenyl (PCB 126) on morphological changes in the developing rat testis
• 발행기관: 한국예방수의학회
• 저자명: 원청길(Chung Kil Won) 김문기(Mun Ki Kim) 박오성(Oh Sung Park) 박현수(Hyeon Soo Park) 최완석(Wan Suk Choi) 김곤섭(Gon Sup Kim)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.35, No.4, 284~290쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.30

영문 초록

This study was conducted to examine the effect of 3,3`, 4,4`, 5-pentachlorobiphenyl (PCB 126) on morphological changes in the developing rat testis. PCB 126 (0.2㎎/㎏/week) in corn oil was weekly i.p. injected into rats from 1 to 11 weeks old. The total body weights and testicular weights were measured at 3, 6, 9 and 12 weeks, respectively. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results demonstrated that PCB 126 treatment caused significant change in the ratio of testicular weight/body weight at 9 week. The treatment of PCB increased the number of pregonium cells at 3 week and it decreased spermatogenesis of the seminiferous tubules at 6 week. The results of this study suggest that PCB 126 can damage the male reproductive organ of the growing rat and that it might be associated with retardation of development of the testis.

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Pentachlorobiphenyl Rat Spermatogenesis Testis