Protective effects of Sasa quelpaertensis nakai extract on radiation-induced oxidative stress in immune cells

• 발행기관: 한국예방수의학회
• 저자명: Areum Kim So Jin Bing Jinhee Cho KHINM Herath Ginnae Ahn EunJin Park Min Ju Kim Dae Seung Kim Ju-S
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.39, No.4, 169~174쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.12.30

영문 초록

Sasa quelpaertensis Nakai is a type of edible bamboo grass distributed on Jeju Island, Korea. S. quelpaertensis has been used as afolk medicine for treatment of a variety of ailments. It has been reported to present biological effects, including anti-inflammatory and antioxidant effects. In this study, we demonstrate that S. quelpaertensis Nakai extract (SNE) rescues immunocytes from gamma radiation-induced apoptosis and oxidative DNA damage. We examined the cytotoxicity, cell proliferation, DNA damage, apoptosis, and generation of reactive oxygen species (ROS) in mice given SNE for 45 days in immune cells. To determine the splenocytes protection capability of SNE, gamma-ray was irradiated to the whole body of C57BL/6 mice. Our results suggest that SNE stimulated the proliferation of splenocytes without cytotoxic effects. In addition, SNE not only decreased DNA damage but also reduced apoptosis of splenocytes, and attenuated the production of ROS generation in hydrogen peroxide-induced splenocytes. Therefore, SNE can protect against gamma radiation-induced damage in mice.

목차

서 론

재료 및 방법

결 과

고 찰

REFERENCES

키워드

Sasa quelpaertensis nakai gamma-rays natural product immune activation