알코올 의존 환자 제독치료에서 벤조다이아제핀의 Fixed-Schedule doses Therapy와 Symptom-Triggered doses Therapy

• 영문명: Fixed-Schedule versus Symptom-Triggered doses of Benzodiazepine Therapy in Detoxification for Alcohol Withdrawal
• 발행기관: 한국중독정신의학회
• 저자명: 이병욱(Byung-Ook Lee) 김정훈(Jung-Hoon Kim)
• 간행물 정보: 『중독정신의학』Vol.9, No.1, 42~47쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.04.30

영문 초록

Objectives：The aim of this study is to investigate the effect and safety of a fixed-schedule therapy and a symptom-triggered therapy of benzodoazepine for alcohol withdrawal. Methods： Subjectives were 31 alcohol dependence patients and randomized to either the fixed-schedule therapy group or the symptomtriggered therapy group using by URN randomization program. URN randomization’s variables were a history of delirium tremens, CIWA-Ar score and a history of excessive alcohol drinking. Total amount of lorazepam administered and duration of medication treatment were measured. Results：The mean lorazepam dose administered in the symptom-triggered therapy group was 8.47 mg compared with 12.3 mg in the fixed-schedule therapy group (p<.05). The mean duration of lorazepam treatment was 69.3 hours in the symptom-triggered therapy group compared with 95.2 hours in the fixed-schedule therapy group (p<.05). Conclusion：Symptom-triggered therapy decreased both the amount of benzodiazepine used and treatment duration, and was as efficacious as fixed-schedule therapy for alcohol withdrawal.

키워드

Alcohol Withdrawal symptom Detoxification