알코올 의존의 치료에서 Naltrexone의 사용

• 영문명: Use of Naltrexone in the Treatment of Alcohol Dependence
• 발행기관: 한국중독정신의학회
• 저자명: 남궁기(Kee Namkoong)
• 간행물 정보: 『중독정신의학』Vol.1, No.1, 14~26쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

Two double-blind placebo controlled clinical trials have demonstrated that naltrexone, a pure opioid antagonist, appears to be an effective adjunct to treatment of alcohol dependence. Naltrexone alters endogenous opioids receptor activity, and its alteration blocks a positive reinforcing effect of alcohol in dopaminergic system. As a result, naltrexone reduces craving for alcohol and alcoholic high. Clinically, naltrexone, which is more compliant than disulfiram in alcoholics, results in fewer drinking days, less drinking amount and lower rate of relapse for alcoholic patients. Especially, those patients who initiatied drinking, patients who received naltrexone and concurrent coping skill/relapse prevention therapy are the least likely to relapse. In addition, a recommendation for morning dosing and the development of a pill taking routine are likely to increase the patients compliance with naltrexone and ultimately the outcome of their treatment for alcoholic dependence. In conclusion, the combined effects of naltrexone, psychosocial therapy and our patient support system need to be explored so that an optimal approach to the treatment of alcoholism, which is suitable for our own situation, should be developed.

목차

서 론

naltrexone의 약리학적 특성

알코올 의존의 치료에서 naltrexone사용의 이론적 근거

알코올 의존의 치료에서 naltrexone의 임상적 효과

알코올 의존 치료 시 naltrexone의 사용 지침(guideline)

결 론

키워드

Naltrexone Alcohol dependence Treatment.