Fluoxetine과 알코올 중독환자 치료 프로그램의 병합 치료가 음주 욕구에 미치는 영향

• 영문명: Effects of Combination Therapy with Fluoxetine and Alcoholics Treatment Program on Alcohol Craving
• 발행기관: 한국중독정신의학회
• 저자명: 박정래(Jeong-Rae Park) 이상익(Sang-Ick Lee) 정인원(In-Won Chung)
• 간행물 정보: 『중독정신의학』Vol.2, No.1, 14~21쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1998.04.30

영문 초록

longterm period abstinence. One of main relapsing factors is alcohol craving. This study is to investigate the efficacy of combination therapy with fluoxetine and psychosocial treatment(Alcoholics Treatment Program) on alcohol craving. The subjects were twenty male alcoholics recovered from acute alcohol intoxication and withdrawal symptoms. They were randomly assigned to combined treatment group or psychosocial treatment group. Each group consists of 10 patients, and received psychosocial treatment program for four weeks. The patients in combined treatment group were administered fluoxetine with fixed dose 60 mg/day and the patients in psychosocial treatment group were administered placebo for four weeks. Alcohol craving was measured by Visual Analogue Scale (VAS), Verbal Rating Scalem (VRS) and the amount of alcohol intake at the baseline, first week, second week and fourth week during the treatment. Mood status also measured by Hamilton Depression Rating Scale (HDRS) at the same time. In combined treatment group, the changes in alcohol craving measured by VAS and VRS was significantly reduced at the second and fourth week, however, depressed mood was different only at fourth week in comparison with psychosocial treatment group. No differences were noted in alcohol craving measured by amount of alcohol intake between two groups. These results show that adjunctive administration of fluoxetine to psychosocial treatment more rapidly reduced alcohol craving than psychosocial treatment only and the effects was not due to improvement of depression. Thus, the combination therapy may be an effective treatment strategy for prevention of relapse in alcoholics.

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키워드

Alcoholism Combination therapy Psychosocialtreatment Fluoxetine 알코올 중독 병합 치료 정신사회 치료 Fluoxetine