Oxidative stress와 질병

• 발행기관: 호서대학교 기초과학연구소
• 저자명: 박선민
• 간행물 정보: 『기초과학연구 논문집』제5권 제1호, 89~103쪽, 전체 15쪽
• 주제분류: 공학 > 공학일반
• 파일형태: PDF
• 발행일자: 1997.08.30

영문 초록

Free radicals are produced continuously at a high rate as a by-product of aerobic metabolism. Free radicals including hydroxyl radical (OH-), H, superoxide (O2), hydroperoxide (HO2)， and CO2 are very reactive and oxidize other molecules such as DNA, lipids, and proteins. These oxidized products, lipid peroxides and lipid hydroperoxides, are oxidative damage, which should be removed. Under normal conditions, a multi- level antioxidant defence system removes reactive oxygen species. The an tioxidant defense system is consisting of antioxidant enzymes (superoxide dismutase, catalase, glutathion peroxidase, glutathion reductase) and free radical scavengers (vitamin E). Consequently, in good health, the exposure of biomolecules to non-specific oxidation by free reactive oxygen spec ie s appears to be minimal.

목차

Abstract

1. 서론

2. 체내에서 free radical의 발생

3. Free radicals의 작용 기전

4. Free radicals와 과산화물의 제거 기전

5. 산화적 스트레스와 심장 혈관계 질환

6. 산화적 스트레스와 당뇨병

7. 결 론

8. 참고문헌