두경부편평세포암에서의 T세포 면역치료

• 영문명: T Cell-directed Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma
• 발행기관: 대한두경부종양학회
• 저자명: 최윤석(Yoon Seok Choi)
• 간행물 정보: 『대한두경부종양학회지』제33권 제1호, 7~13쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2017.05.30

영문 초록

Despite improved treatment outcomes of locally advanced disease over the last 2 decades, the survival of patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains dismal. There is a clear need for development of novel therapeutic strategies for recurrent and/or metastatic HNSCC. Recent advances in understanding tumor immunology have been directly and rapidly translated into clinical success of T cell-directed immunotherapeutic approach in the treatment of several types of solid cancers. Among them, impact of immune checkpoint inhibition using neutralizing antibodies is the most striking. A variety of immunotherapeutic strategies targeting T cells have been also studied in HNSCC, especially in recurrent and/or metastatic setting even with significant survival benefit. The present article reviews the basic concept of T cell-directed immunotherapy and the current status of such approaches in the treatment of HNSCC.

목차

Abstract

서론

T세포 면역치료의 개요

두경부편평세포암에서의 면역관문억제제 치료

두경부편평세포암에서의 수지상세포 백신 치료

두경부편평세포암에서의 T세포 입양면역치료

결론

References

키워드

두경부암 T세포 면역치료 면역관문억제제 head and neck cancer T cell immunotherapy immune checkpoint inhibitor