호흡기 상피 배상세포에서의 점액 과다분비와 관련된 뮤신 유전자 발현 및 생성에 대한 리나룰, 올레아놀산, 베타 카리오필렌의 약리작용

• 영문명: Pharmacological action of Linalool, Oleanolic acid and β-caryophyllene on Gene Expression and Production of Mucin from Goblet cells in Respiratory Epithelium
• 발행기관: 대한약학회
• 저자명: 이현재(Hyun Jae Lee)
• 간행물 정보: 『약학회지』제61권 제2호(2017년), 75~82쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.04.30

영문 초록

We examined whether linalool and other natural products affect airway MUC5AC mucin gene expression and production induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with PMA for 24h. Linalool, β-caryophyllene and oleanolic acid inhibited the gene expression and production of MUC5AC mucin. This result suggests that these three compounds can inhibit the production and gene expression of mucin, through directly acting on airway epithelial cells.

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키워드

Airway mucin linalool