흰쥐의 cis-[$Pt(NH_3)_2Cl_2$ 수식 이미지 신장독성 회복과 Bacillus subtilis의 증식을 위한 디티오카바메이트의 합성, 성질 및 응용

• 영문명: Synthesis, Properties, and Application of Dithiocarbamate for Rescue of cis-[$Pt(NH_3)_2Cl_2$ 수식 이미지] Nephrotoxicity in Rats and Growth of Bacillus subtilis
• 발행기관: 한국환경보건학회
• 저자명: 이우식 김찬우 김인식 김창수
• 간행물 정보: 『한국환경보건학회지』제20권 제3호, 31~38쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

Dithiocarbamates containing polar groups which give very water soluble metal complexes were prepared from the reaction of carbon disulfide with diamines. The compounds have been characterized by elemental analysis, molar conductivity, and spectroscopic results. Dithiocarbamate and its complex were soluble in water. N, N-Dimethylammoniumpropylenedithiocarbamate(A) is clearly effective as inhibition of cis-platinum nephrotoxicity in rats. From the result of A rescue after cis-dichlorodiammineplatinum(II) treatment, it is suggested that dithiocarbamate removes platinum(II) coordinated to -SH groups bound to protein of kidney tubule cells by the reaction of platinum(II) with dithiocarbamate injected. A is effective as antidots for acute cadmium poisoning in Bacillus subtills. Growth of Bacillus subtills may be accelerated by A ligand dissociated from cadmium (II)-A complex.