흰쥐의 만성 카드뮴 중독에 대한 식용 버섯의 전처리효과

• 영문명: Effects of Agaricus bisporus Diet on Organs of Rats Chronically Exposed to Cadmium Chloride
• 발행기관: 한국환경보건학회
• 저자명: 김남송
• 간행물 정보: 『한국환경보건학회지』제21권 제4호, 87~95쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 1995.12.30

영문 초록

The concentrations of cadmium, metallothionein(MT), superoxide dismutase(SOD), and lactate dehydrogenase(LDH) were investigated in liver and kidney of rats which were fed the water containing 100 ppm cadmium chloride with basal diet and 5% Agaricus bisporus diet during 16 weeks. Cadmium concentrations in liver and kidney increased during 16 weeks, and there were significantly higher accumulation of cadmium in the kidney than in the liver. The concentrations of MTs in liver and kidney decreased linearly during 16 weeks, but there was no significant difference between control and experimental group. MT concentrations of liver were significantly higher than those of kidney. The superoxide dismutase activities and lactate dehydrogenase activities were not affected by the diet, but there was a significant difference by the duration of administration. These data indicate that the kidney is a major target organ of chronic cadmium poisoning, and suggest that Cd-induced hepatic injury, via release of Cd-MT, may play an important role in the nephrotoxicity. In conclusion, induction of MT occurs in both the liver and the kidney after administration of $CdCl_2$. However, the kidney is less responsive than the liver to the induction of MT by cadmium, which may contribute to making the kidney the target organ of toxicity during chronic Cd exposure.

키워드

Diet Cadmium Chloride metallothionein(MT) SOD LDH