技齒創 治療時 Fibronectin의 役割에 관한 免疫細胞化學的 硏究

• 영문명: An immunocytochemical study on the effect of fibronectin on the healing process of extracted wound
• 발행기관: 대한구강악안면외과학회
• 저자명: Sang Chun Kim(金相千) Hak won Kim(金學元)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제13권 제1호, 235~249쪽, 전체 15쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1987.06.30

영문 초록

The purpose of this study was to search how fibronectin influences to the extracted wound in the process of its normal healing in dogs. This was studied by histopathological, histochemical, and immunocytochemical means. The dogs, weighing average of 10 ㎏, were employed in this experiment. The third and fourth premolars of mandible were extracted under general anesthesia using Ketamine HCl intramuscular injection, and all surgical procedures were performed under aseptic condition. Two dogs of each groups were sacrified on the 1st, 3rd, 5th, 7th, 10th and 14th day respectively after extraction, and specimens were resected. All the specimens were fixed in 10% neutral formalin solution and decalcified with Planko Richlo solution and embedded in paraffin in the usual manner. The 7-8 ㎛ sectioned specimens were stained with hematoxylineosin, Masson s trichrome and avidin-biotin-peroxidase complex (ABC) technique. The results were as follows: The fibronectin was appeared as a granular or reticular pattern on 3rd day, the amount of fibronectin was gradually increased according to the development of granulation tissue but was markedly reduced according the maturation of granulation tissue. Although the fibronectin was markedly increased around the osteoid tissue, it was reduced on calcifying.

목차

ABSTRACT

I. 緖論

II. 實驗材料 및 方法

III. 實驗成績

IV. 總括 및 考察

V. 結論

參考文獻