구강 암종에서 인체 유두종 바이러스 DNA 검출 및 p53 단백의 과발현과의 상관관계

• 영문명: DETECTION OF HUMAN PAPILLOMAVIRUS AND OVEREXPRESSION OF p53 IN SQUAMOUS CELL CARCINOMAS OF ORAL CAVITY
• 발행기관: 대한구강악안면외과학회
• 저자명: 서찬호(Chan Ho Seo) 이영수(Young Soo Lee) 심광섭(Kwang Sup Shim) 유광희(Kwang Hee Yoo)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제23권 제3호, 388~400쪽, 전체 13쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 1997.07.30

영문 초록

Epidemiological evidence suggests that human papillomavirus(HPV) infection is a high risk factor for the development of oral cancers. Many oncogenes, especially p53 suppressor gene, have a critical role of carcinogenesis in several human cancers including oral cancers. To investigate the prevalence of HPV infection and subtyping of high risk group(HPV-16, -18 and -33) HPV in oral cancers, the author studied 31 cases of squamous cell carcinomas arising from the oral cavity using polymerase chain reaction (PCR). The author also demonstrated the overexpression of p53 oncoprotein in the oral cancers using immunohistochemical methods. The correlation between HPVs infection and p53 overexpression in tumorigenesis of the oral cancers was evaluated. 1. Twenty-one cases(66.7%) among 31 cases of oral squamous cell carcinomas were positive for HPV-DNA. Among them, 16 cases were positive for HPV-16, 4 cases for HPV-18, and 2 cases for HPV-33. Two cases were coinfected with HPV-16 and HPV-18, and HPV-18 and HPV-33. 2. The prevalence of HPV infection appeared not correlated with tumor differentiation and clinical stages of oral squamous cell carcinomas. 3. The overexpression of p53 oncoprotein was present in 24 of 31 cases(77%). In 21 HPV positive tumors 18 cases were positive for overexpression of p53 oncoprotein. Six cases were positive for p53 in ten HPV negative tumors. There was no correlation between HPV DNA detection rate and p53 overexpression. The above results suggest that HPV infection and p53 oncogene mutation play different roles in tumorigenesis of oral squamous cell carcinomas. No coexpression of p53 oncoprotein with HPV-DNA detection suggests that another etiologic mechanism other than HPV infection may be operative.

목차

Abstract

I. 서론

II. 실험재료 및 방법

III. 결과

IV. 고찰

V. 결론

참고문헌

키워드

Oral cancer HPV infection p53 overexpression polymerase chain reaction immunohistochemical stain