원지, 애기풀 및 소초의 염산·에탄올로 유발된 흰쥐 위염에 대한 억제 효과

• 영문명: Inhibitory Effects of Polygala tenuifolia Willd., Polygala japonica and Polygala tenuifolia on HCl·ethanol-induced Gastritis in Rats
• 발행기관: 대한약학회
• 저자명: 황인영(In Young Hwang) 이선이(Sun Yi Lee) 서유경(Suh Yoo Kyung) 정춘식(Choon Sik Jeong)
• 간행물 정보: 『약학회지』제61권 제1호(2017년), 24~29쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.02.28

영문 초록

Alcohol, coffee, salty and spicy foods, excessive acid secretion, and NSAIDs increase risk of having a gastritis. Helicobacter pylori (H. pylori), in particular, is known to be a pathogen that is capable of causing gastritis and gastric cancer. Reactive oxygen species and oxidative stress may also play a role as a major factor in gastric injury. In this study, we studied extracts of Polygala tenuifolia Willd. (root), Polygala japonica and Polygala tenuifolia (sprout) for their inhibitory effects on HCl·ethanol-induced gastritis in rats. As a result, extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, reducing power, inhibitory effect on H. pylori colonization and acid-neutralizingcapacity. Especially, the extracts of Polygala tenuifolia Willd. and Polygala japonica significantly inhibited HCl·ethanol-induced gastritis in rat. The results obtained indicate that these extracts might be useful for preventing gastritis.

목차

서 론

실험재료 및 방법

고 찰

결 론

감사의 말씀

References

키워드

antioxidant Helicobacter pylori gastritis