소포체 스트레스를 매개한 curcumin의 폐암세포주 사멸효과

• 영문명: Curcumin-induced Apoptotic Cell Death Mediated by ER Stress in Lung Carcinoma Cell Lines
• 발행기관: 대한약학회
• 저자명: 오지윤(Ji Youn Oh) 김소현(Sou Hyun Kim) 곽재환(Jae Hwan Kwak) 정영석(Young Suk Jung)
• 간행물 정보: 『약학회지』제61권 제1호(2017년), 12~17쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.02.28

영문 초록

In the present study, we investigated the effect of curcumin, a major well-known compound isolated from rhizomes of Curcuma longa, on the apoptotic cell death and the potential action mechanism of this effect in human lung carcinoma cell lines. The results showed that curcumin inhibited the cell viability in a concentration-dependent manner in both H292 and H358 human lung carcinoma cells. Treatment of curcumin activated caspase-3 evidenced by increased cleaved protein of caspase-3, and subsequently, induced cleavage of PARP. In line with this, Annexin V/PI staining clearly showed that curcumin-induced apoptosis in both cell lines. Interestingly, CCAAT-enhancer-binding protein homologous protein (CHOP), a key molecule involved in endoplasmic recticulum (ER) stress-mediated apoptosis, was significantly increased by curcumin treatment. Collectively, the results suggest that ER stress via CHOP induction might play a significant role in curcumin- induced apoptotic death of human lung carcinoma cells.

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재료 및 방법

실험결과 및 고찰

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감사의 말씀

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키워드

Lung cancer Curcumin Apoptosis ER stress