정제봉독의 반복 첩포 피부자극시험

• 영문명: Repeated Skin Irritation Test of Purified Bee Venom from Honeybee(Apis mellifera L.) in Rabbits
• 발행기관: 대한약학회
• 저자명: 한상미(Sang Mi Han) 홍인표(In Phyo Hong) 우순옥(Soon Ok Woo) 김세건(Se Gun Kim) 장혜리(Hye Ri Jang) 박관규(Kyun Kyu Park)
• 간행물 정보: 『약학회지』제61권 제1호(2017년), 1~5쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.02.28

영문 초록

This study was performed to examine the repeated skin irritation reaction of purified bee venom (Apis mellifera L.) collected using bee venom collector. To confirm whether the purified bee venom causes primary skin irritation when used for the skin medicinal products, skin irritation testing was conducted using rabbit models. The purified bee venom (0.5 mg/kg/day) was uniformly applied on each gauze patch cut into a size of approximately 2.5 cm×2.5 cm. Then, each patch was pasted to the skin, respectively, and was fixed with an adhesive plaster. The left was controls and the right was purified bee venom for 7 days everyday. Observations were made at 1, 24, 48 and 72 hours after the patch had been removed, and then the irritation reaction was scored according to Formation of erythema and eschar and edema. No irritation reaction was observed in any of the test skins during the observation period. Therefore, the P.I.I, was 0. As a result, no irritation reaction was observed in any of the test skins during the observation period. Therefore, in the primary skin irritation test using rabbits, the purified bee venom was judged to belong to a category “non-irritant”. This study demonstrated that purified bee venom has promising potential external treatment for topical uses that do not induce significant levels of skin reaction.

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실험결과 및 고찰

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감사의 말씀

References

키워드

honeybee venom skin irritation rabbit erythema edema