산화알루미늄 나노물질이 랫드의 대뇌와 신장에 미치는 영향

• 영문명: Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys
• 발행기관: 한국환경보건학회
• 저자명: 조은혜(Eunhye Jo) 서균백(Gyun-Baek Seo) 김현미(Hyunmi Kim) 최경희(Kyunghee Choi) 권정택(Jung-Taek Kwon) 김필제(Philje Kim) 엄익춘(Igchun Eom)
• 간행물 정보: 『한국환경보건학회지』제42권 제1호, 27~33쪽, 전체 7쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2016.02.28

영문 초록

Objectives: Alumina nanoparticles (Al 2 O 3 , Al-NPs) are used for various purposes, including as coating agents and paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploring the toxic effects on the brain and kidneys caused by Al-NPs exposure in rats. Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 days following OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and gene expression analysis were conducted on the rats. Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expression levels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in cell differentiation, transcription and signal transduction. In the rat kidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to AlNPs, including other genes encoding proteins involved in apoptosis, transcription and signal transduction. Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney and cerebrum, and it can be a toxic indicators of nanometrials.

목차

1. 서 론

II. 연구내용 및 방법

III. 결 과

IV. 고 찰

V. 결 론

키워드

Aluminum oxide nanoparticles toxicogenomics