Endocrine Disruption Potentials of Bisphenol A Alternatives

• 발행기관: 한국환경보건학회
• 저자명: Kyunghee Ji Kyungho Choi
• 간행물 정보: 『한국환경보건학회지』제39권 제1호, 1~18쪽, 전체 18쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2013.02.28

영문 초록

Objectives: Although a great body of knowledge is available on the toxicity of bisphenol A (BPA), little is known about that of BPA alternatives, such as bisphenol analogues (BPs) or TritanTM copolyesters. This review provides a summary of the available information on the toxicity of BPs and three components of TritanTM, with a special focus on endocrine disruption. Methods: We collected from the literature a battery of in vitro and in vivo assay data developed to assess endocrine disruption of four BPs (bisphenol AF, B, F, and S) and three major components of TritanTM ((di-methylterephthalate (DMT), 1,4-cyclohexanedimethanol (CHDM), and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD)). Results: Several alternative compounds were identified as possessing comparable or even greater endocrinedisrupting effects than BPA in in vitro and in vivo studies. Conclusions: Potential endocrine disruption of BPA alternatives requires further studies on health consequences in experimental animals and in humans following longer term exposure.

키워드

bisphenols endocrine disruption Tritan