백서에서 흡수성막과 탈회동결건조골을 이용한 두개골결손부의 골재생

• 영문명: GUIDED BONE REGENERATION OF CALVARIAL BONE DEFECTS USING BIOABSORBABLE MEMBRANE AND DEMINERALIZED FREEZE DRIED BONE IN RATS
• 발행기관: 대한구강악안면외과학회
• 저자명: 김수민(Soo-Min Kim) 여환호(Hwan-Ho Yeo) 김수관(Su-Gwan Kim) 임성철(Sung-Chul Lim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제4호, 290~301쪽, 전체 12쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.08.30

영문 초록

The purpose of this study was to evaluate new bone formation and healing process in rat calvarial bone defects using BioMesh membrane and DFDB. Forty eight rats divided equally into 4 groups of 1 control group and 3 experimental groups. Standardized transosseous circular calvarial defects (8 mm in diameter) were made midparietally. In the control group, the defect was only covered with the soft tissue flap. In the experimental group 1, it was filled with DFDB only, in the experimental group 2, it was covered BioMesh membrane only, and in the experimental group 3, it was filled DFDB and covered with membrane. At the postoperative 1, 2, 4, 8 weeks, rats were sacrificed and histologic and histomorphometric analysis were performed. These results were as follows. In histomorphometric analysis, It showed the greatest amount of new bone formation through experimental in the experimental group 3 (P<0.001). The amount of new bone formation at the central portion of the defect was greater in the experimental group 3 than experimental group 2. BioMesh􀋓 membrane began to resorb at 1 week and resorbed almost completely at 8 weeks after operation. The collapse of membrane into the defect was observed through the experimental periods in the experimental group 2. In the area of collapsed membrane, new bone formation was restricted. These results suggest that maintenance of some space for new bone to grow is required in the use of BioMesh membrane alone in the defect. It is also thought that use of the membrane may promote new bone growth in DFDB graft.

키워드

Guided bone regeneration Calvaria Bioabsorbable membrane BioMesh Demineralized freeze dried bone Rat