가토 상악동에 이식된 β-TCP의 골치유에 관한 실험적 연구

• 영문명: THE EXPERIMENTAL STUDY OF THE BONE REGENERATION ON RABBIT MAXILLARY SINUS GRAFTING WITH β-TCP
• 발행기관: 대한구강악안면외과학회
• 저자명: 박정하(Jung-Ha Park) 황경균(Kyung-Gyun Hwang) 박창주(Chang-Joo Park) 최용수(Yong-Soo Choi) 마평수(Pyung-Soo Ma) 백승삼(Seung-Sam Paik) 심광섭(Kwang-Sup Shim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제32권 제2호, 107~116쪽, 전체 10쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Purpose:Maxillay sinus grafting is an effective treatment procedure to improve bone height in the posterior maxillar area for implant installation. Beta-tricalciumphosphate(β-TCP) was introduced to be grafting substitute material, providing a reasonable bio-degradation time, no need for harvesting procedure. The purpose of this study is to evaluate bone healing & regeneration phase using histomorphometric and immunohistochemical analysis. Material & Methods:Sixteen rabbits were divided into 4 groups. Bi-lateral maxillary sinus membranes were elevated at each rabbits, β-TCP was augmented in left sinus, autogenous bone was augmented in right sinus. The rabbits were sacrificed at 2, 4, 8 and 12 weeks. We investigated the bone regeneration & growth factor expression. Results: 1. The mean new bone volume formation was 28.99±6.55%, 49.54±5.47%, 69.09±8.90% in autogenous grafted area, and 22.86±5.56%, 24.00±4.09%, 34.11±3.37% in β-TCP area at 4, 8, 12 weeks. Therefore, new bone formation in autogenous bone was significantly higher than β-TCP (p<0.05). 2. The BMP 2/4 expression in autogenous bone grafted area was higher at 4, 8 weeks. 3. There was no difference in expression pattern of BMP-7/PDGF/VEGF during grafted bone regeneration. Conclusion:The authors we conclude that the autogenous bone graft was faster than β-TCP in bone regeneration, and the BMP 2/4 were more important in graft bone regeneration.

키워드

β-TCP Rabbit Maxillary sinus