구강편평세포암종에서의 Cisplatin 유도 아폽토시스에서의 NF-κB의 활성화

• 영문명: ACTIVATION OF NF-κB IN THE CISPLATIN-INDUCED APOPTOSIS OF ORAL SQUAMOUS CELL CARCINOMA
• 발행기관: 대한구강악안면외과학회
• 저자명: 서종천(Jong-Chun Seo) 성일용(Iel-Yong Sung) 김종렬(Jong-Roul Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제32권 제2호, 94~100쪽, 전체 7쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2006.04.30

영문 초록

Purpose: This study was done to confirm the role of NF-κB in cisplatin-induced apoptosis of oral squamous cell carcinoma. Materials and Methods: Five cell lines originated from different oral cancer patients were tested for the apoptosis by the treatment of cisplatin. These cells showed different degree of cisplatin-resistance and the order is OSCC-2> OSCC-3> OSCC-5> OSCC-1> OSCC-4. OSCC-2 and OSCC-4 cells were assayed for the apoptosis by measuring DNA fragmentation and TUNEL staining after cisplatin treatment. While OSCC-4 cells showed apoptosis, OSCC-2 cells showed no or very slight apoptosis by cisplatin treatment. Next, It was determined whether NF-κB activation is required in mediating cisplatin-induced apoptosis of OSCC-4 . Result: The result was that elevated NF-κB activity mediated cisplatin-induced apoptosis. Conclusion: In conclusion, these findings suggest that NF-κB activation is essential to cisplatin-induced apoptosis and it may be involved in cisplatin resistance in OSCC cells.

키워드

Apoptosis NF-κB Cisplatin