구강 편평 상피 암종에서 TGF-β1과 MMP-2의 발현과 경부 임파절 전이 간의 상관 관계에 관한 연구

• 영문명: THE CLINICAL SIGNIFICANCE OF THE EXPRESSION OF TGF-β1 AND MMP-2 RELATED TO THE REGIONAL LYMPH NODE METASTASIS IN THE ORAL SQUAMOUS CELL CARCINOMA
• 발행기관: 대한구강악안면외과학회
• 저자명: 김좌영(Jwa-Young Kim) Horatiu Rotaru 김성곤(Seong-Gon Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제3호, 199~203쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.06.30

영문 초록

Several matrix metalloproteinases (MMPs) have been shown to play an important role in the invasion and metastasis of oral squamous cell carcinoma(OSCC). The members of the TGF-βsignaling pathway are being considered as predictive biomarkers for progressive tumorigenesis and molecular targets for the prevention and the treatment of cancer and metastasis. The aim of the present study was to find the clinical significance of the expression of TGF-β1 and MMP-2 related to the regional lymph node metastasis in OSCC. This study included 76 cases of primary OSCC, of which 42 cases showed regional lymph node metastases. Immunohistochemistry was used for the localization of protein. The relation between the expression of each protein and clinical variables was statistically evaluated. In results, the expression of TGF-β1 both main mass with lymph node metastasis and without lymph node metastasis was found not to be statistically significant (p>0.05). The expression of MMP-2 was found to be statistically significant related to regional lymph node metastasis (p<0.05). When compared the expression in the metastatic lymph node, TGF-β1 was significantly highly expressed than MMP-2 (p<0.05). In conclusion, the expression of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to the patients without lymph node metastasis, which could be useful in predicting the risk of lymph node metastasis in OSCC.

키워드

Oral squamous cell carcinoma(OSCC) Matrix metalloproteinase-2(MMP-2) TGF-β1 Metastasis