칼슘과 비타민 D 섭취가 티타늄 임플랜트 주위의 골 형성에 미치는 영향

• 영문명: EFFECT OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON BONE FORMATION AROUND TITANIUM IMPLANT
• 발행기관: 대한구강악안면외과학회
• 저자명: 박광일(Kwang-Il Park) 이재열(Jae-Yeol Lee) 황대석(Dae-Seok Hwang) 김용덕(Yong-Deok Kim) 김규천(Gyoo-Cheon Kim) 신상훈(Sang-Hun Shin) 김욱규(Uk-Kyu Kim) 정인교(In-Kyo Chung)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제2호, 130~137쪽, 전체 8쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.04.30

영문 초록

The purpose of this study was to observe the effect of calcium and vitamin D to the titanium implant osseointegration in animal model. 32 rats, 10 weeks of age, were divided into two group: additional calcium and vitamin D supplementation group and a control group. Titanium screw implant(diameter, 2.0mm; length, 3.5mm; pitch-height 0.4 ㎜) were placed into tibia of 32 rats, 16 in the control group and 16 in the experimental group. The rats were sacrificed at different time interval(1, 2, 4, and 8 weeks after implantation) for histopathologic observation, histomorphometric analysis and immunohistochemistry with osteocalcin and osteopontin antibody. Histopathologically findings, newly formed bone was seen at 1 weeks and became lamellar bone at 2 weeks, and mature trabecullar bone was seen at 4 weeks experimental group. In control group, thickness of regenerated bone increased till 4 weeks gradually and trabecullar bone was seen at 8 weeks. By histomorphometric analysis, bone marrow density was increased significantly at 1 and 2 weeks in experimental group compared to control group. Osteocalcin immunoreactivity was strong at 1 week experimental group and reduced after 4 weeks gradually. But it was continuously weakly from 1 to 4 weeks in control group. Osteopontin immunoreactivity was very strong in newly formed bone from 2 to 8 weeks experimental group. And the amount of osteopontin expression was more abundant in experimental group. The results of this study suggest that calcium and vitamin D supplementation promotes bone healing around dental implants

키워드

Calcium Vitamin D Implant