법랑모세포종에서 Receptor Activatorof Nuclear Factor-ĸB Ligand(RANKL)와 Osteoprotegerin(OPG) 발현에 관한 연구

• 영문명: IDENTIFICATION OF RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-ĸB LIGAND(RANKL) AND OSTEOPROTEGERIN(OPG) IN AMELOBLASTOMA
• 발행기관: 대한구강악안면외과학회
• 저자명: 하우헌(Woo-Hun Ha) 황대석(Dae-Seok Hwang) 김용덕(Yong-Deok Kim) 신상훈(Sang-Hun Shin) 김욱규(Uk-Kyu Kim) 김종렬(Jong-Ryoul Kim) 정인교(In-Kyo Chung)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제33권 제2호, 94~102쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2007.04.30

영문 초록

The ameloblastoma is a common odontogenic tumor of the jaw bone and represents approximately 1% of tumor in the jaw. However, it might be able to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. In this study, expression of RANKL and OPG in ameloblastoma in relation to age and gender of patient and recurrence, location of the lesion were examined through immunohistochemisry study. The RANKL and OPG antibody staining were used. The obtained result were as follow. 1. Positive immunoreactivity to RANKL/OPG in all specimens was found. 2. 1n recurrenc, location of ameloblastoma and age, gender of patients using immunohistochemical expression of RANKL. There was not significant difference. 3. 1n recurrence, location of ameloblastoma and age, gender of patients using immunohistochemical expression of OPG. There was not significant difference. In summary, it is suggested that activation of osteoclasts by RANKL is an important mechanism by which ameloblastomas cause bone destruction.

키워드

Ameloblastoma RANKL OPG