토끼의 하악골에서 β-TCP와 rhBMP-2의 골형성 효과에 대한 형태계측학적 연구

• 영문명: Morphometric analysis on bone formation effect of β-TCP and rhBMP-2 in rabbit mandible
• 발행기관: 대한구강악안면외과학회
• 저자명: 김규남(Kyu-Nam Kim) 양정은(Jung-Eun Yang) 장재원(Jea-Won Jang) 사시카라 바라라만(Balaraman Sasikala) 왕붕(Wang Beng) 김일규(Il-Kyu Kim)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면회과학회지 제36권 제3호, 161~171쪽, 전체 11쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Introduction: This study was to assess the effectiveness of new bone formation and regeneration by using a rhBMP-2 and β-TCP as a carrier in rabbits’mandible. Materials and Methods: The mandibles of 36 rabbits were exposed and cortical bone was penetrated for this study. The experimental subjects were divided into 3 groups each 12 rabbits ; control group, experimental group 1, and experimental group 2. Control group had the defect itself without any treatment, in the experimental group 1, β-TCP only was grafted, and in the experimental group 2, rhBMP-2 soaked in β-TCP was grafted. The rabbits were sacrificed after 1, 2, 3, 4, 6, and 8weeks, and new bone formation area was examined and measured for bone quantitative and qualitative analysis with light, fluorescent and polarized microscopy. Results: In the experimental group 1, new bone formation from the adjacent host bone was made by osteoconduction, and in the experimental group 2, direct new bone formation by osteoinduction of rhBMP-2 as well as new bone formation by osteoconduction of β-TCP were observed. Conclusion: rhBMP-2 of experimental group 2 is very effective in the bone formation in early 2weeks and bone remodelling from 3weeks

키워드

Bone morphogenetic protein Tricalcium Phosphate (TCP) Osteoconduction Osteoinduction