아세톤이 마우스 피부 조직의 ROS에 미치는 영향

• 영문명: Effect of Acetone on Reactive Oxygen Species to Mice Skin
• 발행기관: 한국인체미용예술학회
• 저자명: 최혜정(Hye-Jung Choi) 이상희(Sang-Hee Lee)
• 간행물 정보: 『한국인체미용예술학회지』한국인체미용예술학회지 제17권 제2호, 45~55쪽, 전체 11쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2016.05.30

영문 초록

Acetone is one of the organic solvents that causes skin barrier disruption such as eczema and dermatitis, ichthyosis and xerosis, and ROS (reactive oxygen species) paly a role of skin toxicity. This study is focused on investigating the effect of ROS of applied acetone. Acetone was applied to mice skin (0.25ml/㎠) four times (6h, 12h, 18h, 24h) every day for two or four days. Increased activity of acid phosphatase (ACP) and increased content of lipid peroxide (LPO) in acetone was determined in the applied group for four days(4ACE) compared with the acetone applied group for two days (2ACE). As for the ROS generating enzymes, one of them, xanthine oxidase (XO) showed no differences between control and 2ACE despite the significantly different 4ACE. There were some differences between 2ACE and 4ACE on the activities of cytochrome P450 dependent aniline hydroxylase (CYPdAH), which seemed to be the increased rates of acetone metabolites. There were more decreased rates of the activities of ROS scavenging enzymes, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutae (SOD), glutathione S-transferase (GST), and glutathione (GSH) contents in 4ACE compared with 2ACE. The results indicate that the damaged skin tissue could cause unbalance of the ROS generating system and scavenging system by the frequent exposure of acetone application.

목차

Ⅰ. 서론

Ⅱ. 실험방법

Ⅲ. 실험결과 및 고찰

Ⅳ. 결론

참고문헌

키워드

Acetone(아세톤) Reactive oxygen species(활성산소종) Generating system(생성계) Scavenging system(해독계)