유리체내 베바시주맙과 라니비주맙 주입술이 전신 순환에 미치는 영향

• 영문명: Effects of Intravitreal Injection of Bevacizumab or Ranibizumab on Systemic Circulation
• 발행기관: 대한안과학회
• 저자명: 윤명헌(Myung Hun Yoon) 김영준(Young Jun Kim) 이소영(So Young Lee) 이강원(Kang Won Lee) 진희승(Hee Seung Chin)
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume57,number3, 429~437쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.03.31

국문 초록

목적: 유리체내 항혈관내피성장인자 주입술 전후로 항혈관내피성장인자와 혈관내피성장인자의 혈중 농도가 어떻게 변화하는지 알아보았다. 대상과 방법: 총 28명의 망막 질환 환자를 대상으로 하여 17명에게 bevacizumab 1.25 mg을, 11명에게 ranibizumab 0.5 mg을 유리체내로 주입하였다. 주입 직전과 주입 후 1일, 1주, 1달에 혈액 샘플을 채취하여 혈중 anti-vascular endothelial growth factor (anti-VEGF) 농도와 VEGF 농도를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. 결과: Bevacizumab 투여 전 anti-VEGF 농도는 91.0 ng/mL에서 1일, 1주, 1달 후 각각 153.6, 196.3, 140.3 ng/mL로 증가하였고(각각 p＜0.05), VEGF 농도는 투여 전 93.9 pg/mL에서 1일, 1주, 1달 후 각각 40.1, 24.7, 33.5 pg/mL로 감소하였다(각각 p＜0.05). Ranibizumab 투여 전 anti-VEGF 농도는 177.6 ng/mL에서 1일, 1주, 1달 후 각각 177.5, 160.7, 175.3 ng/mL로 유의한 변화가 없었고 (각각 p＞0.05), VEGF 농도도 투여 전 80.9 pg/mL에서 1일, 1주, 1달 후 각각 96.7, 106.3, 106.1 pg/mL로 유의한 변화가 없었다(각각 p＞0.05). 결론: Ranibizumab과 달리 bevacizumab은 유리체내 주입술 후 혈중 VEGF 농도를 유의하게 낮췄다. 따라서 유리체내 bevacizumab 주입술의 전신적인 영향에 대한 고려가 필요할 수 있다.

영문 초록

Purpose: The purpose of this study was to evaluate the systemic effects of ranibizumab and bevacizumab by examining the plasma levels of anti-vascular endothelial growth factor (anti-VEGF) and VEGF before and after a single intravitreal injection. Methods: Twenty-eight eyes of 28 patients with various retinal diseases were enrolled. Seventeen eyes received an injection of intravitreal bevacizumab, and 11 eyes received an injection of ranibizumab. Blood samples were collected just before and 1 day, 1 week, and 1 month after injection. Concentrations of anti-VEGF and VEGF in plasma were measured using enzyme-linked immunosorbent assay (ELISA). Results: In the bevacizumab group, anti-VEGF concentration before the injection was 91.0 ng/mL, while those at 1 day, 1 week, and 1 month post-injection increased to 153.6, 196.3, and 140.3 ng/mL, respectively (p < 0.05 for all). VEGF concentration before the injection was 93.9 pg/mL, while those 1 day, 1 week, and 1 month post-injection were reduced to 40.1, 24.7, and 33.5 pg/mL, respectively (p < 0.05 for all). However, in the ranibizumab group, no significant reductions in anti-VEGF concentration were observed. The anti-VEGF concentration before the injection was 177.6 ng/mL, while those at 1 day, 1 week, and 1 month post-injection were 177.5, 160.7, 175.3 ng/mL, respectively (p > 0.05 for all). VEGF level also showed no significant change. VEGF concentration before the injection was 80.9 pg/mL, while those at 1 day, 1 week and 1 month post-injection were 96.7, 106.3, 106.1 pg/mL, respectively (p > 0.05 for all). Conclusions: Contrary to ranibizumab, intravitreal bevacizumab significantly lowers plasma VEGF level in patients with various retinal diseases. The study suggests the consideration of the systemic effects of intravitreal bevacizumab injection.

목차

Abstract

대상과 방법

결과

고찰

REFERENCES

국문초록

키워드

Anti-vascular endothelial growth factor (anti-VEGF) Bevacizumab Ranibizumab Vascular endothelial growth factor(VEGF)