쥐 대식세포에 대한 고추나무(Staphylea bumalda) 잎의 항염증 효과 검증

• 영문명: Anti-inflammatory Effects of Staphylea bumalda Leaves Extracts in Murine Macrophages
• 발행기관: 대한약학회
• 저자명: 김정화(Jeong Hwa Kim) 이재권(Jae Kwon Lee)
• 간행물 정보: 『약학회지』제59권 제6호(2015년), 251~258쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.12.31

영문 초록

Aim of the present study was to investigate whether methanol extract from the leaves of Staphylea bumalda could be used to suppress lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage cell lines, Raw 264.7 cells. The extract reduced nitric oxide (NO), cyclooxigenase-2 (COX-2) and pro-inflammatory cytokines production from LPS-stimulated Raw 264.7 cells. These inhibitory effects were associated with decreases in the phosphorylation of MAP kinases and the activity of NFκB signal pathways. Our results indicate that Staphylea bumalda significantly inhibits the inflammatory activity of activated macrophages, suggesting that Staphylea bumalda could be a potential candidate for the treatment of inflammatory disease.

키워드

Staphylea bumalda nitric oxide cytokine anti-inflammation macrophages