3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) 화합물의 항콕시디움 효과

• 영문명: Anticoccidial Effect of 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108)
• 발행기관: 대한약학회
• 저자명: 여선주(Seon-Ju Yeo) 김학성(Hak Sung Kim) 김석(Suk Kim) 이기인(Kee-In Lee) 박현(Hyun Park)
• 간행물 정보: 『약학회지』제59권 제6호(2015년), 266~269쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.12.31

영문 초록

Abstract—Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by 33±2.64% and 23±3.60% (P<0.001) at 7th day and 9th day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.

키워드

Toxoplasma gondii Eimeria tenella anticoccidial effect selectivity 5-108