측경부 림프절 전이를 동반한 갑상선 유두상암의 임상 양상과 면역조직화학적 특성

• 발행기관: 대한두경부종양학회
• 저자명: 이선욱(Seon Uk Lee) 진성민(Sung Min Jin) 이상혁(Sang Hyuk Lee) 손진희(Jin Hee Sohn) 채승완(Seung Wan Chae) 김동훈(Dong Hoon Kim)
• 간행물 정보: 『대한두경부종양학회지』제27권 제1호, 59~65쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2011.05.30

영문 초록

Background and Objectives：Papillary thyroid carcinoma(PTC) frequently metastasize to the regional neck, however, lateral neck lymph node metastasis is less common. The aim of this study is to investigate clinical and immunohistochemical features of PTC with lateral LN metastasis, and determine the predictive factors for lateral LN metastases. Material and Methods：We undertook a retrospective study of 83 patients treated between January 2007 and December 2009 for PTC by thyroidectomy with or without lateral neck dis-section. The following criteria were used to study the clinical predictive value of lateral LN. metastases : sex, age, tumor size, multifocality, extracapsular spread(ECS) and lymphovascular emboli. Immunohistochemical staining for VEGF-A, VEGF-C, Bax, Bcl-2, Cyclin D1, Cyclin E, p27 kip1 and p57 kip2 was performed, and quantified blindly by three pathologists who had no clinical information of the patients. Immunohistochemical expression was scored as high(＞50% of cells stained) or low(0-49%). Results：With use of univariate and multivariate analysis, tumor size(＞2cm) and ECS were independent correlates of lateral LN metastasis in PTC. Expression of VEGF-C, Bax, and Cyclin D1 in the PTC with lateral LN metastasis was scored higher than in PTC without lateral LN metastasis(p＜0.05). Conclusion：The important risk factors for lateral LN metastasis in PTC are primary tumor size and the presence of ECS. And expression of VEGF-C, Bax and cy-clin D1 may be considered of lateral LN metastatic potential in PTC.

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키워드

Thyroid papillary carcinoma Lymphatic metastasis Immunohistochemistry 갑상선 유두상암 림프절 전이 면역조직화학.