두경부암에서 저용량 Cisplatin 기반 매주 요법의 항암방사선 동시치료의 독성과 예비 임상 결과

• 영문명: The Toxicity and Preliminary Clinical Outcomes of Low-Dose Weekly Cisplatin-Based Concurrent Chemoradiotherapy
• 발행기관: 대한두경부종양학회
• 저자명: 김태용(Tae-Yong Kim) 김경주(Kyoung Ju Kim) 김기환(Ki Hwan Kim) 김지은(Ji Eun Kim) 박선원(Sun-Won Park) 오소원(So Won Oh) 정영호(Young Ho Jung)
• 간행물 정보: 『대한두경부종양학회지』제27권 제1호, 47~53쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2011.05.30

영문 초록

Purpose：Concurrent chemoradiotherapy(CCRT) with 3 weekly cisplatin is the standard treatment of lo-cally advanced head and neck cancer(HNC). The aim is to evaluate the efficacy and toxicities of low-dose week-ly cisplatin-based CCRT, which was devised to reduce the toxicity of CCRT. Method：We retrospectively ana-lyzed HNC patients who received low-dose weekly cisplatin-based CCRT between 2008 and 2010. Cisplatin 35mg/m 2 was weekly given to all patients during radiotherapy. The efficacy was evaluated by the degree of clinical response, treatment failure and survival. The toxicity was evaluated by hematologic toxicities and oral mucositis. Results：A total of 27 patients were analyzed and median age was 59(range 31-81). The ratio of administered dose of radiotherapy and cisplatin to planned dose were 0.98 and 0.93, respectively. Complete re-mission and partial remission were 73% and 23%, respectively. Treatment failure was observed in 8(30%) pa-tients. 1-year survival rate and 1-year disease free survival rate were 82% and 59%, respectively. Overall surviv-al and progression-free survival did not reach median time. Grade 3/4 anemia, neutropenia, thrombocytopenia and oral mucositis were observed in 11%, 19%, 7% and 32% of patients, respectively. In terms of administered cycles, however, only 1-3% of grade 3/4 hematologic toxicities occurred among total 190 cycles. Severe oral mucositis were statistically associated with old age(p=0.003). Treatment failure had no statistical relation with age, pathology, primary site and stage. Conclusion：Low-dose weekly cisplatin-based CCRT seemed to deliv-er enough dose of cisplatin and to show low drop-out rate and good efficacy with low hematologic toxicities.

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Head and neck cancer Toxicity Chemoradiotherapy 두경부암 독성 항암방사선치료.