구강암편평세포암에서 c-Met 발현여부에 따른 (-)-Epigallocatechin-3-Gallate의 세포사멸 및 종양침습억제효과의 변화분석

• 영문명: Analysis of (-)-Epigallocatechin-3-Gallate-Induced Apoptosis and Inhibition of Invasiveness in Oral Cavity Carcinoma Squamous Cell Carcinoma According to Expression of c-Met
• 발행기관: 대한두경부종양학회
• 저자명: 신유섭(Yoo Seob Shin) 고윤우(Yoon Woo Koh) 최은창(, Eun Chang Choi) 강성운(Sung Un Kang) 황혜숙(Hye Sook Hwang) 추옥성(Oak-Sung Choo) 이한빈(Han Bin Lee) 김철호(Chul-Ho Kim)
• 간행물 정보: 『대한두경부종양학회지』제27권 제1호, 3~11쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2011.05.30

영문 초록

Hepatocyte growth factor(HGF) and c-Met play an important role in the control of tumor growth and inva-sion, and they are known to be good prognostic indicators of patient outcome. Epigallocatechin-3-gallate (EGCG) has been shown to have chemopreventive and therapeutic properties by modulating multiple signal pathways regarding the control of proliferation and invasion of cells. In this study, we evaluated the role of c-Met in EGCG-induced inhibition of invasion and apoptosis in an oral cancer cell line. In KB cells where c-Met was knocked down with siRNA, we performed invasion assay and FACS with Annexin V-FITC/PT staining. In addition, we checked the change of mitochondrial membrane potential(MMP) and the generation of reactive ox-ygen species(ROS). EGCG-induced inhibition of invasiveness was significantly decreased after the knock-down of c-Met. EGCG-induced apoptosis, MMP change and ROS generation was also reduced in c-Met knock-ed-down KB cells. These results suggest that c-Met is involved in EGCG-induced apoptosis and inhibition of invasiveness of oral cancer cell line.

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HGF(Hepatocyte Growth Factor) c-Met EGCG Oral cavity cancer Apoptosis Invasion 간세포성장인자 c-Met EGCG 구강암 세포 사멸 침습