구인두 암에서 방사선 치료의 효과 ; 단일기관의 경험

• 영문명: The Effects of Radiotherapy for Oropharyngeal Cancer ; A Single Institutional Experience
• 발행기관: 대한두경부종양학회
• 저자명: 최은철(Euncheol Choi) 김옥배(Ok Bae Kim) 오영기(Young Kee Oh) 김미영(Mi Young Kim) 여창기(Chang Ki Yeo) 변상준(Sang Jun Byun) 박승규(Seung Gyu Park) 김진희(Jin Hee Kim)
• 간행물 정보: 『대한두경부종양학회지』제30권 제2호, 62~67쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2014.11.30

영문 초록

Background and Objectives：To investigate the prognostic factors and effectiveness of radiotherapy for oro-pharyngeal cancer. Material and Methods：Forty seven patients in oropharyngeal cancer treated with radiothera-py between November 1989 and October 2010. Conventional radiotherapy was performed until July 2007 and conformal radiotherapy was performed since August 2007. Median age of patients was 59. Thirty five patients were males. Nine patients had operation. Patients treated with postoperative radiotherapy were delivered median 60 Gy and patients treated with definitive radiotherapy were delivered median 66 Gy. Median follow-up periods were 51 months. Results： Two year and 5 year overall survival rate was 78.7% and 59.9%. Two year and 5-year locoregional recurrence free survival rate was 82.3% and 72.9%. In subgroup of definitive radiotherapy, at uni- variate analysis for overall survival, lower N stage(p=0.01), lower stage(p=0.05) and well and moderate differen-tiation(p=0.001) were statistically significant. At univariate analysis for locoregional recurrence free survival, lower T stage(p=0.02) and better differentiation(p=0.043) were statistically significant. Treatment failure occurred in 12 patients. Locoregional recurrence(8 patients) was main pattern of failure. Conclusion：When definitive ra-diotherapy compared with postoperative adjuvant radiotherapy, there was no significant difference. Further stud-ies would be needed to compare definitive radiotherapy with postoperative radiotherapy. N stage, stage and dif-ferentiation could be the prognostic factors for overall survival and T stage and differentiation could be the prognostic factors for locoregional recurrence free survival in patients treated definitive radiotherapy.

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대상 및 방법

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키워드

Oropharyngeal neoplasm Radiotherapy Prognosis Treatment outcome 구인두 신생물 방사선 치료 예후 치료 결과.