Isoflavone-Free 검은콩펩타이드의 항고혈압 및 ACE 활성 억제효과

• 영문명: Antihypertensive and ACE Inhibitory Effects of Novel Isoflavone-free Black Soy Peptide Mixture
• 발행기관: 대한약학회
• 저자명: 안창원(Chang-Won Ahn) 신동석(Dong-Seok Shin) 박수현(Soo-Hyun Park) 홍순선(Soon-Sun Hong) 강주희(Ju-Hee Kang) 박창신(Chang-Shin Park)
• 간행물 정보: 『약학회지』제56권 제5호 (2012년), 309~313쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.10.31

영문 초록

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from 33.2±4.5 to 27.4±1.96 mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from 213.0±16.96 to 184.0±6.53 mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.

키워드

isoflavone-free peptide mixture ACE SHR antihypertension