서장경으로부터 분리한 Homosyringaldehyde의 뇌신경세포 보호 활성

• 영문명: Neuroprotectuve Effect of Homosyringaldehyde Isolated from Cynanchum panuculatum against Glutamate-Induced Neurotoxicity
• 발행기관: 대한약학회
• 저자명: 원진배(Jin Bae Weon) 이보형(Bohyoung Lee) 윤보라(Bo-Ra Yun) 이지우(Jiwoo Lee) 마충제(Choong Je Ma)
• 간행물 정보: 『약학회지』제56권 제5호 (2012년), 299~303쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.10.31

영문 초록

Homosyringaldehyde was isolated and identified from the 80% methanol extract of roots of Cynanchum paniculatum. C. paniculatum has been widely used for the treatment of various diseases such as neurasthenia, insomnia, dysmenorrheal and toothache. This compound exerted significant neuroprotective activities against glutamate-induced neurotoxicity in hippocampal HT22 cell line by 37.53% (at the concentration of 100 μM). We investigated mode of action of this compound. Homosyringaldehyde (100 μM) significantly decreased the ROS level and Ca2+ concentration in the oxidative stress induced HT22 cells by oxidative glutamate toxicity. Thus, our results suggest that homosyringaldehyde significantly protect HT22 cells against glutamate-induced oxidative stress, via antioxidative activities. As the results, we suggest that homosyringaldehyde may be useful in the treatment of neurogenerative disorders.

키워드

Homosyringaldehyde Cynanchum paniculatum neuroprotective effect HT22 cells glutatmate