오미자 리그난 화합물의 베타-아밀로이드간 결합 억제 및 해리 효과

• 영문명: Effect of Lignan Components from Schizandra chinensis on Beta-amyloid Aggregation Inhibition and Dissociation
• 발행기관: 대한약학회
• 저자명: 유호진(Ho Jin Yu) 윤미소(Mi So Yoon) 김도윤(Do Yoon Kim) 원경종(Kyung-Jong Won) 김보경(Bokyung Kim) 장상희(Sang-Hee Jang) 이환명(Hwan Myung Lee)
• 간행물 정보: 『약학회지』제56권 제5호 (2012년), 293~298쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.10.31

영문 초록

The present study tested the effect of Schizandra chinensis lignan compounds, Gomisin A and Schizandrin, on the aggregation and dissociation of beta-amyloid (Aβ)1-42 to explore a possible therapeutic target for Alzheimer's disease. Gomisin A significantly inhibited the Aβ1-42 aggregation in a dose dependent manner, but did not induced the dissociation of aggregated Aβ1-42. On the other hand, Schizandrin significantly suppressed the aggregation and dissociation of Aβ1-42. These results suggest that Gomisin A and Schizandrin, which are known as biologically active ingredients from Schizandra chinensis, may be potentially useful target molecules to develop a drug for the prevention or treatment of Alzheimer's disease.

키워드

Schizandra chinensis Alzheimer's disease beta-amyloid Schizandrin Gomisin