지실 추출물의 전사인자 SREBP-1 활성에 의한 지질 생성 촉진

• 영문명: Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation
• 발행기관: 대한약학회
• 저자명: 김대성(Dae Sung Kim) 전병국(Byoung Kook Jeon) 문연자(Yeun Ja Mun) 이강태(Ghang Tai Lee) 이건국(Kun Kuk Lee) 우원홍(Won Hong Woo)
• 간행물 정보: 『약학회지』제56권 제4호 (2012년), 268~273쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.31

영문 초록

This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-β and PPAR-γ but not that of PPAR-α. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-β and PPAR-γ activations.

키워드

Ponciri fructus lipogenesis SREBP-1 PPARs sebocyte