새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성

• 영문명: Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent
• 발행기관: 대한약학회
• 저자명: 강진아(Jin-Ah Kang) 천부순(Pusoon Chun) 문형룡(Hyung Ryong Moon)
• 간행물 정보: 『약학회지』제56권 제4호 (2012년), 230~235쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.31

영문 초록

Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives 2~8 with α-configuration was successfully accomplished using an epoxide-ring opening reaction, lactonization, a hydroboration-oxidation reaction and a Mitsunobu reaction as the key steps. Antiviral activities against HSV-1 and -2, HIV-1 and -2, coxsackie B1and B3 viruses and poliovirus were assayed. Three compounds 4, 7 and 8 exhibit cytotoxicity-derived antiviral activity only in HIV-1 and -2.

키워드

HSV nucleosides Mitsunobu reaction virus α-configuration