염산부플로메딜 정과 염산티클로피딘 정의 용출시험법 개발

• 영문명: Development of Dissolution Test Method for Buflomedil Hydrochloride Tablets and Ticlopidine Hydrochloride Tablets
• 발행기관: 대한약학회
• 저자명: 이륜경(Ryun-Kyung Lee) 정경록(Gyeong-Rok Jeong) 오현숙(Hyun-Sook Oh) 심지연(Jee-Youn Shim) 서상철(Sang-Chul Suh) 이효정(Hyo-Jung Lee) 김민아(Min-A Kim) 박성민(Seong-Min Park) 이규하(Kyu-Ha Lee) 손경희(Kyung-Hee Sohn) 김인규(In-Kyu Kim) 사홍기(Hong-Kee Sah) 최후균(Hoo-Kyun Choi) 조태용(Tae-Yong Cho) 홍충만(Choong-Man Hong)
• 간행물 정보: 『약학회지』제56권 제4호 (2012년), 211~216쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.31

영문 초록

Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.

키워드

dissolution test buflomedil-HCl ticlopidine-HCl