페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성

• 영문명: Synthesis and α-Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues
• 발행기관: 대한약학회
• 저자명: 장인혜(Inhye Chang) 이은영(Eunyoung Lee) 황보경(Kyoung Hwangbo) 김인규(In-Kyu Kim) 손경희(Kyung-Hee Sohn) 최란(Lan Choi) 이응석(Eung-Seok Lee) 우미희(Mi Hee Woo) 손종근(Jong-Keun Son) 나영화(Younghwa Na)
• 간행물 정보: 『추계총회 및 학술대회』(2002년) vol.2, 446~450쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.10.30

영문 초록

As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.

키워드

α-glucosidase piperazine analogues type 2 diabetes