항염증효과를 갖는 2'-하이드록시찰콘 유도체의 합성

• 영문명: Synthesis of Anti-inflammatory 2'-Hydroxychalcone Derivatives
• 발행기관: 대한약학회
• 저자명: 이영숙(Young Sook Lee) 김학성(Hak Sung Kim)
• 간행물 정보: 『약학회지』제55권 제5호 (2011년), 367~373쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.10.31

영문 초록

It was reported that the potency of TMMC derivatives was related to the presence of the 2'-hydroxy group on the A ring. Also, 4-dimethylamino group on the B ring lowered the anti-inflammatory potency of the chalcones. We synthesized various derivatives of 2'-hydroxy chalcones having other substituents on B ring. The synthetic derivatives showed the more potent anti-inflammatory effect, comparable to that of the TMMC derivatives reported previously.

키워드

chalcone 2'-hydroxy group anti-inflammatory TMMC