메틸크로만-2-카르복실산 N-(이치환)페닐아마이드 유도체의 NF-κB 저해 구조-활성 상관 관계

• 영문명: Structure Activity Relationship of Methylchroman-2-carboxylic Acid N-(Disubstituted)phenylamide Derivatives as Potential NF-κB Inhibitors
• 발행기관: 대한약학회
• 저자명: 김태정(Tae-Jeong Kim) 곽재환(Jae-Hwan Kwak) 김영수(Youngsoo Kim) 정재경(Jae-Kyung Jung) 이희순(Heesoon Lee)
• 간행물 정보: 『약학회지』제55권 제2호 (2011년), 154~159쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.30

영문 초록

During the search for a novel compound that can inhibit NF-κB activation, 6-hydroxy-7-methoxychroman-2- carboxylic acid phenyl amide (KL-1156) was identified as a good inhibitor of NF-κB activation. In the present study, we describe the synthesis of methylchroman-2-carboxylic acid N-(disubstituted)phenylamide derivatives (1 and 2 serieses). In addition, their inhibitory effects of NF-κB are compared with activity of KL-1156 and SAR (structure activity relationship) are explored.

키워드

NF-κB KL-1156 methylchroman SAR