Malonyl Dihalide를 이용한 새로운 α-Amidoketenes의 합성

• 영문명: Synthesis of New α-Amidoketenes Using Malonyl Dihalide
• 발행기관: 대한약학회
• 저자명: 오미정(Mi-Jung Oh) 박명숙(Myung-Sook Park)
• 간행물 정보: 『약학회지』제55권 제2호 (2011년), 127~130쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.30

영문 초록

We synthesized new α-amidoketenes using dehydrochlorination from anilines, triethylamine and malonyl dichloride under 0oC. The utility of ketenes in both laboratory and industrial practice was quickly recognized, and these species have been extensively utilized, including as pharmaceutical intermediates and anti-cancer agents. All synthetic process from anilines to α-amidoketenes could be carried out by one-pot reaction. Synthetic ketenes 2a~f were identified using NMR and IR spectrum. Formation of ketenes was undertaken with dropping of malonyl dichloride at 0oC in methylene chloride for 0.5~4 h. Using malonyl dichloride was better than using diethyl malonate as a synthetic reagents for the ketenes.

키워드

α-amidoketenes acylketenes acylhalides synthesis dehydrochlorination 3-oxo-acrylamide