동맥혈관 평활근세포 증식에 대한 오보바톨 유도체(A-8)의 억제효과

• 영문명: Inhibitory Effects of A-8 on Abnormal Rat Aortic Vascular Smooth Muscle Cell Proliferation
• 발행기관: 대한약학회
• 저자명: 임용(Yong Lim) 이미애(Mi-Yea Lee) 투데브멍흐(Munkhtsetseg Tudev) 박은석(Eun-Seok Park) 정재경(Jae-Kyung Jung) 윤여표(Yeo-Pyo Yun)
• 간행물 정보: 『약학회지』제55권 제2호 (2011년), 116~120쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.30

영문 초록

Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression of proliferative cardiovascular diseases, including hypertension and atherosclerosis. To find antiproliferative agent (A)-8 had inhibitory effect on VSMCs proliferation. Therefore, we examined the antiproliferative effect of A-8, a newly synthesized obovatol derivative. To investigate the antiproliferative effect of A-8, we examined cell counting and [3H]-thymidine incorporation assays. The pre-incubation of A-8 (1~4 μM) significantly inhibited proliferation and DNA synthesis of 5% fetal bovine serum (FBS)-stimulated rat aortic VSMCs in concentration-dependent manner. Whereas, A-8 did not show any cytotoxicity in rat aortic VSMCs in this experimental condition by WST-1 assay. In addition, A-8 significantly inhibited 5% FBS-induced cell cycle progression in rat aortic VSMCs. These results show that A-8 may be developed as a potential antiproliferative agent for treatment of angioplasty restenosis and atherosclerosis. Furthermore, A-8 should be examined for further clinical application either as a single agent or in combination with other angioplasty restenosis or atherosclerosis agents.

키워드

atherosclerosis smooth muscle cell FBS obovatol