무균조제 항암제 취급의 안전관리

• 영문명: Assessment of Occupational Exposure to Antineoplastic Agents in a Healthcare Setting
• 발행기관: 대한약학회
• 저자명: 이수미(Su Mi Lee) 정선영(Seon Young Chung) 임현정(Hyun Jeong Im) 박효정(Hyo Jung Park) 이수연(Su Yun Lee) 전은용(Eun Yong Jeon) 손기호(Kie Ho Sohn)
• 간행물 정보: 『약학회지』제55권 제2호 (2011년), 81~90쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.04.30

영문 초록

Most antineoplastic agents are nonselective in their mechanism of action, affecting noncancerous as well as cancerous cells, and resulting in acute effects such as irritation of mucous membranes and chronic effects such as genotoxicity, teratogenicity, and carcinogenicity. Healthcare workers occupationally exposed to antineoplastic agents are at risk. The present study aimed to develop and apply methods to monitor occupational exposure to antineoplastic agents, using cyclophosphamide (CP) as the model compound. To monitor environmental and biological exposure, potentially contaminated surfaces were wiped and 24 hour urine samples were collected from workers. Liquid chromatography combined with tandem mass spectrometry was performed, with a limit of detection of 0.05 ng/ml. Measurable amounts of CP were detected on 92% of the sampled surfaces, with a geometric mean of 175.22 ng/m2. Despite the environmental contamination of the model compound, CP was below the detection limit in all urine samples. If workplace contamination cannot be completely avoided, it is importance to reduce exposure to the lowest possible levels. To this aim, efforts to minimize occupational exposure along with biological and environmental monitoring are required. The standardized sampling techniques, and specific and sensitive analytical methods reported in this study may be helpful in assessing occupational exposure and devising strategies to reduce exposure.

키워드

antineoplastic drugs biological monitoring hospital work environment surface contamination