Effects of antibiotic consumption on children 2-8 years of age developing asthma

• 발행기관: 한국역학회
• 저자명: Hamid Reza Khalkhali Sima Oshnouei Shaker Salarilak Mohammadhossein Rahimi Rad Mohammad Karamyar Javad Khashabi
• 간행물 정보: 『Epidemiology and Health』36, 1~4쪽, 전체 3쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2014.06.30

영문 초록

OBJECTIVES: Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age. METHODS: A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic chil-dren based on Global Initiative for Asthma criteria (n= 207), and the controls were children without respirato-ry symptoms (n= 400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing par-ents/guardians. RESULTS: Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symp-toms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p< 0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p= 0.03). CONCLUSIONS: Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.

목차

Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Antibiotic use Childhood asthma Case-control studies