Effects of low concentration of clarithromycin to Danio rerio after acute exposure through metabolic analysis

• 발행기관: 한국방재학회
• 저자명: Ryan De Sotto Carl Medriano Young ja Park Sung pyo Kim
• 간행물 정보: 『3. 한국방재학회 학술대회논문집』2015년, 101~101쪽, 전체 1쪽
• 주제분류: 공학 > 기타공학
• 파일형태: PDF
• 발행일자: 2015.02.25

영문 초록

The presence of pharmaceuticals in the environment has led to apparent toxicity with different aquatic species. Clarithromycin, for example, is used in treating respiratory tract infections, has been recently found in the surface waters and rivers which might threaten non-targeted organisms in these matrices. In this study, a model vertebrate Danio rerio (zebrafish) was exposed to 100ppb clarithromycin for 72 hours to evaluate acute toxicity through significantly affected metabolic compounds in the fish's pathway. Metabolites obtained from q-TOF LC/MS were identified and mapped with the zebrafish's metabolic pathway using Metlin, and KEGG respectively. 335 compounds are believed to have been significantly altered by the acute exposure of the antibiotic with the fish. The most affected pathways are ABC transporters, steroid hormone biosynthesis, arachidonic acid metabolism, purine metabolism, and biosynthesis of amino acids. With the said findings, it can be concluded that, although concentration of some pharmaceuticals may be as low as the one used in this study, its effects on the aquatic species exposed to it might be significant and should be given immediate attention

키워드

Metabolomics Clarithromycin Danio rerio