세프트리악손 투여와 관련된 폐쇄성 망막혈관염

• 영문명: Occlusive Retinal Vasculitis Associated with Intravenous Ceftriaxone Injection
• 발행기관: 대한안과학회
• 저자명: 석주용 이승재 오민진 이수영,Ju Yong Seok, MD, Seung Jae Lee, MD, Min Jin Oh, MD, Soo Young Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number3, 508~512쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.03.15

영문 초록

Purpose: To report a case of bilateral occlusive retinal vasculitis presumed to be associated with intravenous ceftriaxone injection. Case summary: A 26-year-old woman presented with a sudden visual impairment which developed 2 days earlier in her left eye combined with an anaphylactoid reaction. The patient was administered intravenous ceftriaxone (2 g / day) 9 times for 14 days due to aggravation of chronic osteomyelitis on her left ankle. There were no adverse events until the 7th intravenous ceftriaxone administration. However, anaphylactoid reactions occurred shortly after the 8th and 9th administration. On the 1st visit, her best corrected visual acuity in the right eye was 1.0, and in the left eye 0.1. On fundus examination, retinal hemorrhages and perivascular sheathing were observed in the superonasal area in the right eye and in the entire retina in the left eye. Anterior chamber cell reactions were not noted on slit lamp examination, and vitritis was absent in both eyes. Laboratory data showed no conclusive evidence of autoimmune or origin of infection. On the last visit, 25 months after the initial visit, the patient’s best corrected visual acuity was 0.02 in the left eye and visual acuity and fundus appearance were normal in the right eye. Conclusions: Bilateral occlusive retinal vasculitis may be associated with intravenous ceftriaxone injection, and immunological and serological tests should be performed thoroughly along with history taking to clarify the cause of retinal vasculitis.

키워드

Ceftriaxone, Drug allergy, Hypersensitivity, Retinal vasculitis